Ontology highlight
ABSTRACT:
SUBMITTER: International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)
PROVIDER: S-EPMC3712260 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20080120 2
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (lambda(S) = approximately 30). We performed a genome-wide association scan using 317,501 SNPs in 720 women of European ancestry with SLE and in 2,337 controls, and we genotyped consistently associated SNPs in two additional independent sample sets totaling 1,846 affected women and 1,825 controls. Aside from the expected strong association between SLE and the HLA reg ...[more]