Ontology highlight
ABSTRACT:
SUBMITTER: Rastogi D
PROVIDER: S-EPMC3712321 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rastogi Deepa D Suzuki Masako M Greally John M JM
Scientific reports 20130101
While DNA methylation plays a role in T-helper (Th) cell maturation, its potential dysregulation in the non-atopic Th1-polarized systemic inflammation observed in obesity-associated asthma is unknown. We studied DNA methylation epigenome-wide in peripheral blood mononuclear cells (PBMCs) from 8 obese asthmatic pre-adolescent children and compared it to methylation in PBMCs from 8 children with asthma alone, obesity alone and healthy controls. Differentially methylated loci implicated certain bio ...[more]