Ontology highlight
ABSTRACT:
SUBMITTER: Gogineni A
PROVIDER: S-EPMC3712991 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gogineni Alvin A Caunt Maresa M Crow Ailey A Lee Chingwei V CV Fuh Germaine G van Bruggen Nicholas N Ye Weilan W Weimer Robby M RM
PloS one 20130716 7
Tumor-associated lymphatics are postulated to provide a transit route for disseminating metastatic cells. This notion is supported by preclinical findings that inhibition of pro-lymphangiogenic signaling during tumor development reduces cell spread to sentinel lymph nodes (SLNs). However, it is unclear how lymphatics downstream of SLNs contribute to metastatic spread into distal organs, or if modulating distal lymph transport impacts disease progression. Utilizing murine models of metastasis, lo ...[more]