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Ghrelin receptors in non-Mammalian vertebrates.


ABSTRACT: The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered 3?years later, in 1999, and our understanding of the physiological significance of the ghrelin system in vertebrates has grown steadily since then. Although the ghrelin system in non-mammalian vertebrates is a subject of great interest, protein sequence data for the receptor in non-mammalian vertebrates has been limited until recently, and related biological information has not been well organized. In this review, we summarize current information related to the ghrelin receptor in non-mammalian vertebrates.

SUBMITTER: Kaiya H 

PROVIDER: S-EPMC3713435 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Ghrelin receptors in non-Mammalian vertebrates.

Kaiya Hiroyuki H   Kangawa Kenji K   Miyazato Mikiya M  

Frontiers in endocrinology 20130717


The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered 3 years later, in 1999, and our understanding of the physiological significance of the ghrelin system in vertebrates has grown steadily since then. Although the ghrelin system in non-mammalian vertebrates is a subject of great interest, protein sequence data for the receptor in non-mammalian vertebrates has been limited until recently, and related biological  ...[more]

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