MRI biomarkers for post-traumatic epileptogenesis.
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ABSTRACT:
SUBMITTER: Immonen R
PROVIDER: S-EPMC3713441 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
MRI biomarkers for post-traumatic epileptogenesis.
Immonen Riikka R Kharatishvili Irina I Gröhn Olli O Pitkänen Asla A
Journal of neurotrauma 20130711 14
The present study tested a hypothesis that early identification of injury severity with quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting increased seizure susceptibility and epileptogenesis after traumatic brain injury (TBI). TBI was induced by lateral fluid percussion injury (FPI) in adult rats. Quantitative T2, T1ρ, and diffusion were assessed with MRI at 9 days, 23 days, or 2 months post-TBI in the perilesional cortex, thalamus, and hippocampus. Seizure suscept ...[more]
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