Ontology highlight
ABSTRACT:
SUBMITTER: Heinrichs S
PROVIDER: S-EPMC3713455 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Heinrichs Stefan S Conover Lillian F LF Bueso-Ramos Carlos E CE Kilpivaara Outi O Stevenson Kristen K Neuberg Donna D Loh Mignon L ML Wu Wen-Shu WS Rodig Scott J SJ Garcia-Manero Guillermo G Kantarjian Hagop M HM Look A Thomas AT
eLife 20130716
A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. Here we show that MYBL2, a gene within the 20q CDR, is expressed at sharply reduced levels in CD34+ cells from most MDS cases (65%; n = 26), whether or not they harbor 20q abnormalities. In a murine competitive reconstitution model, Mybl2 knockdown by RNAi to 20-30% of normal levels in multipot ...[more]