Ontology highlight
ABSTRACT:
SUBMITTER: Jiang L
PROVIDER: S-EPMC3713518 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Jiang Lin L Liu Cong C Leibly David D Landau Meytal M Zhao Minglei M Hughes Michael P MP Eisenberg David S DS
eLife 20130716
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic diseases, ignorance of amyloid structure has hindered similar approaches to amyloid disease. Here we show that knowledge of the atomic structure of one of the adhesive, steric-zipper segments of the amyloid-beta (Aβ) protein of Alzheimer's disease, ...[more]