Ontology highlight
ABSTRACT:
SUBMITTER: Callen E
PROVIDER: S-EPMC3713552 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Callen Elsa E Di Virgilio Michela M Kruhlak Michael J MJ Nieto-Soler Maria M Wong Nancy N Chen Hua-Tang HT Faryabi Robert B RB Polato Federica F Santos Margarida M Starnes Linda M LM Wesemann Duane R DR Lee Ji-Eun JE Tubbs Anthony A Sleckman Barry P BP Daniel Jeremy A JA Ge Kai K Alt Frederick W FW Fernandez-Capetillo Oscar O Nussenzweig Michel C MC Nussenzweig André A
Cell 20130530 6
The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologous recombination (HR). During S phase, BRCA1 antagonizes 53BP1 to promote HR. The pro-NHEJ and antirecombinase functions of 53BP1 are mediated in part by RIF1, the only known factor that requires 53BP1 phosphorylation for its recruitment to double-strand breaks (DSBs). Here, we show that a 53BP1 phosphomutant, 53BP18A, c ...[more]