Ontology highlight
ABSTRACT:
SUBMITTER: Nix MA
PROVIDER: S-EPMC3714013 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Nix Matthew A MA Kaelin Christopher B CB Ta Tina T Weis Allison A Morton Gregory J GJ Barsh Gregory S GS Millhauser Glenn L GL
Chemistry & biology 20130601 6
The β-defensins are a class of small, cationic proteins first recognized as antimicrobial components of the innate and adaptive immune system. More recently, one of the major β-defensins produced in skin, β-defensin 3, has been discovered to function as a melanocortin receptor ligand in vivo and in vitro, but its biophysical and pharmacological basis of action has been enigmatic. Here, we report functional and biochemical studies focused on human β-defensin 3 (HBD3) and melanocortin receptors 1 ...[more]