Dataset Information

ZIP4 is a novel molecular marker for glioma.

ABSTRACT:

Background

Dysregulated zinc transport has been observed in many cancers. However, the status of zinc homeostasis and the expression profile of zinc transporters in brain and brain tumors have not been reported.

Methods

The gene profiles of 14 zinc importers (ZIPs) and 10 zinc exporters (ZnTs) in patients with glioma were studied by investigating the association between the zinc transporters and brain tumor characteristics (tumor grade and overall survival time). Three independent cohorts were analyzed to cross-validate the findings: the Chinese Glioma Genome Atlas (CGCA) cohort (n = 186), the US National Cancer Institute Repository for Molecular Brain Neoplasia Data (REMBRANDT) cohort (n = 335), and The University of Texas (UT) cohort (n = 34).

Results

The expression of ZIP3, 4, 8, 14, ZnT5, 6, and 7 were increased, and the expression of ZnT10 was decreased in grade IV gliomas, compared with grade II gliomas. Among all 24 zinc transporters, ZIP4 is most significantly associated with tumor grade and overall survival; this finding is consistent across 2 independent cohorts (CGCA and REMBRANDT) and is partially validated by the third cohort (UT). High ZIP4 expression was significantly associated with higher grade of gliomas and shorter overall survival (hazard ratio = 1.61, 95% confidence interval = 1.02-2.53, P = .040 in CGCA cohort; hazard ratio = 1.32, 95% confidence interval = 1.08-1.61, P = .007 in REMBRANDT cohort).

Conclusions

Dysregulated expression of zinc transporters is involved in the progression of gliomas. Our results suggest that ZIP4 may serve as a potential diagnostic and prognostic marker for gliomas.

SUBMITTER: Lin Y

PROVIDER: S-EPMC3714151 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Publications

ZIP4 is a novel molecular marker for glioma.

Lin Yi Y Chen Yong Y Wang Yongzhi Y Yang Jingxuan J Zhu Vivian F VF Liu Yulun Y Cui Xiaobo X Chen Leon L Yan Wei W Jiang Tao T Hergenroeder Georgene W GW Fletcher Stephen A SA Levine Jonathan M JM Kim Dong H DH Tandon Nitin N Zhu Jay-Jiguang JJ Li Min M

Neuro-oncology 20130417 8

<h4>Background</h4>Dysregulated zinc transport has been observed in many cancers. However, the status of zinc homeostasis and the expression profile of zinc transporters in brain and brain tumors have not been reported.<h4>Methods</h4>The gene profiles of 14 zinc importers (ZIPs) and 10 zinc exporters (ZnTs) in patients with glioma were studied by investigating the association between the zinc transporters and brain tumor characteristics (tumor grade and overall survival time). Three independent ...[more]

PMID: 23595627

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Dataset Information

ZIP4 is a novel molecular marker for glioma.

Background

Methods

Results

Conclusions

Publications

ZIP4 is a novel molecular marker for glioma.

Similar Datasets

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