Ontology highlight
ABSTRACT:
SUBMITTER: Miranda-Hernandez S
PROVIDER: S-EPMC3714200 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Miranda-Hernandez Socorro S Baxter Alan G AG
American journal of clinical and experimental immunology 20130227 1
Multiple Sclerosis (MS) is an autoimmune disease in which Central Nervous System (CNS) lesions result from perivascular immune cell infiltration associated with damage to myelin, oligodendrocytes and neurons. CNS autoimmunity and its regulation are dominated by the inflammatory cytokines IL17 and IFNγ, and the opposing regulatory cytokines IL10 and the type I IFNs. Toll-like receptors (TLR) play a critical role in modulating cytokine and chemokine secretion in response to exogenous Pathogen Asso ...[more]