Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC3714371 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Clinica chimica acta; international journal of clinical chemistry 20130326
<h4>Background</h4>The loss of synaptic function is a pivotal mechanism in the development of Alzheimer's Disease (AD). Structural changes and loss of plasticity in the postsynaptic density (PSD) may contribute to the pathogenesis. However, the underlying molecular events triggering synaptic dysfunction remain elusive. We report a quantitative proteomic analysis of the PSD from human postmortem brain tissues of possible and definite AD cases.<h4>Methods</h4>The analysis used both discovery and t ...[more]