Ontology highlight
ABSTRACT:
SUBMITTER: Meuth SG
PROVIDER: S-EPMC3714864 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Meuth Sven G SG Kleinschnitz Christoph C Broicher Tilman T Austinat Madeleine M Braeuninger Stefan S Bittner Stefan S Fischer Stephan S Bayliss Douglas A DA Budde Thomas T Stoll Guido G Wiendl Heinz H
Neurobiology of disease 20080930 1
Oxygen depletion (O(2)) and a decrease in pH are initial pathophysiological events in stroke development, but secondary mechanisms of ischemic cell death are incompletely understood. By patch-clamp recordings of brain slice preparations we show that TASK1 and TASK3 channels are inhibited by pH-reduction (42+/-2%) and O(2) deprivation (36+/-5%) leading to membrane depolarization, increased input resistance and a switch in action potential generation under ischemic conditions. In vivo TASK blockad ...[more]