Ontology highlight
ABSTRACT:
SUBMITTER: Kohli L
PROVIDER: S-EPMC3715566 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Kohli Latika L Kaza Niroop N Coric Tatjana T Byer Stephanie J SJ Brossier Nicole M NM Klocke Barbara J BJ Bjornsti Mary-Ann MA Carroll Steven L SL Roth Kevin A KA
Cancer research 20130530 14
Tamoxifen is widely used to treat estrogen receptor-positive breast cancer. Recent findings that tamoxifen and its derivative 4-hydroxytamoxifen (OHT) can exert estrogen receptor-independent cytotoxic effects have prompted the initiation of clinical trials to evaluate its use in estrogen receptor-negative malignancies. For example, tamoxifen and OHT exert cytotoxic effects in malignant peripheral nerve sheath tumors (MPNST) where estrogen is not involved. In this study, we gained insights into t ...[more]