Ontology highlight
ABSTRACT:
SUBMITTER: Easterhoff D
PROVIDER: S-EPMC3716189 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Easterhoff David D Ontiveros Fernando F Brooks Lauren R LR Kim Yoel Y Ross Brittany B Silva Jharon N JN Olsen Joanna S JS Feng Changyong C Hardy Dwight J DJ Dunman Paul M PM Dewhurst Stephen S
Antimicrobial agents and chemotherapy 20130318 6
The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In light of the fact that other amyloidogenic peptides have been shown to possess direct antibacterial activity, we investigated whether SEVI could inhibit bacterial growth. Neither SEV ...[more]