Ontology highlight
ABSTRACT:
SUBMITTER: Battula VL
PROVIDER: S-EPMC3716201 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Battula V Lokesh VL Chen Ye Y Cabreira Maria da Graca Mda G Ruvolo Vivian V Wang Zhiqiang Z Ma Wencai W Konoplev Sergej S Shpall Elizabeth E Lyons Karen K Strunk Dirk D Bueso-Ramos Carlos C Davis Richard Eric RE Konopleva Marina M Andreeff Michael M
Blood 20130605 3
Mesenchymal stromal cells (MSCs) are a major component of the leukemia bone marrow (BM) microenvironment. Connective tissue growth factor (CTGF) is highly expressed in MSCs, but its role in the BM stroma is unknown. Therefore, we knocked down (KD) CTGF expression in human BM-derived MSCs by CTGF short hairpin RNA. CTGF KD MSCs exhibited fivefold lower proliferation compared with control MSCs and had markedly fewer S-phase cells. CTGF KD MSCs differentiated into adipocytes at a sixfold higher rat ...[more]