Unknown

Dataset Information

0

Use of nonsteroidal anti-inflammatory drugs and bladder cancer risk: a meta-analysis of epidemiologic studies.


ABSTRACT:

Purpose

Several epidemiologic studies have evaluated the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and bladder cancer risk and the results were varied. Thus, we conducted a comprehensive meta-analysis of studies exclusively dedicated to the relationship between the 3 most commonly used analgesics and bladder cancer risk.

Methods

A systematic literature search up to November 2012 was performed in PubMed database for 3 categories of analgesics: acetaminophen, aspirin or non-aspirin NSAIDs. Study-specific risk estimates were pooled using a random-effects model.

Results

Seventeen studies (8 cohort and 9 case-control studies), involving a total of 10,618 bladder cancer cases, were contributed to the analysis. We found that acetaminophen (relative risk [RR] 1.01, 95% confidence interval [CI] 0.88-1.17) and aspirin (RR 1.02, 95% CI 0.91-1.14) were not associated with bladder cancer risk. Although non-aspirin NSAIDs was statistically significantly associated with reduced risk of bladder cancer among case-control studies (but not cohort studies), the overall risk was not statistically significant (RR 0.87, 95% CI 0.73-1.05). Furthermore, we also found that non-aspirin NSAIDs use was significantly associated with a 43% reduction in bladder cancer risk among nonsmokers (RR 0.57, 95% CI 0.43-0.76), but not among current smokers.

Conclusion

The results of our meta-analysis suggest that there is no association between use of acetaminophen, aspirin or non-aspirin NSAIDs and bladder cancer risk. However, non-aspirin NSAIDs use might be associated with a reduction in risk of bladder cancer for nonsmokers.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC3716767 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Use of nonsteroidal anti-inflammatory drugs and bladder cancer risk: a meta-analysis of epidemiologic studies.

Zhang Haifeng H   Jiang Dongpeng D   Li Xuedong X  

PloS one 20130719 7


<h4>Purpose</h4>Several epidemiologic studies have evaluated the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and bladder cancer risk and the results were varied. Thus, we conducted a comprehensive meta-analysis of studies exclusively dedicated to the relationship between the 3 most commonly used analgesics and bladder cancer risk.<h4>Methods</h4>A systematic literature search up to November 2012 was performed in PubMed database for 3 categories of analgesics: acetaminophen,  ...[more]

Similar Datasets

| S-EPMC6155958 | biostudies-literature
| S-EPMC3749466 | biostudies-literature
| S-EPMC2395299 | biostudies-other
| S-EPMC3951299 | biostudies-literature
| S-EPMC5323148 | biostudies-literature
| S-EPMC6490752 | biostudies-literature
| S-EPMC5731974 | biostudies-literature
| S-EPMC4214884 | biostudies-literature
| S-EPMC3556848 | biostudies-other
| S-EPMC5716792 | biostudies-literature