Ontology highlight
ABSTRACT:
SUBMITTER: Ocak S
PROVIDER: S-EPMC3717253 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ocak Sebahat S Pedchenko Tetyana V TV Chen Heidi H Harris Frederick T FT Qian Jun J Polosukhin Vasiliy V Pilette Charles C Sibille Yves Y Gonzalez Adriana L AL Massion Pierre P PP
The European respiratory journal 20110929 5
Polymeric immunoglobulin receptor (pIgR) expression is downregulated in lung cancer, but its implications in lung tumourigenesis remain unknown. We hypothesised that loss of pIgR expression occurs early, and is associated with cell proliferation and poor prognosis. pIgR expression was evaluated by immunohistochemistry in airways of patients with normal mucosa, pre-invasive lesions and invasive lesions, and correlated with clinical outcomes. 16-HBE and A549 cells stably transfected with pIgR were ...[more]