Ontology highlight
ABSTRACT:
SUBMITTER: Khodabakhshi AH
PROVIDER: S-EPMC3717795 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Khodabakhshi Alireza Hadj AH Morin Ryan D RD Fejes Anthony P AP Mungall Andrew J AJ Mungall Karen L KL Bolger-Munro Madison M Johnson Nathalie A NA Connors Joseph M JM Gascoyne Randy D RD Marra Marco A MA Birol Inanc I Jones Steven J M SJ
Oncotarget 20121101 11
Somatic hypermutation (SHM) in the variable region of immunoglobulin genes (IGV) naturally occurs in a narrow window of B cell development to provide high-affinity antibodies. However, SHM can also aberrantly target proto-oncogenes and cause genome instability. The role of aberrant SHM (aSHM) has been widely studied in various non-Hodgkin's lymphoma particularly in diffuse large B-cell lymphoma (DLBCL). Although, it has been speculated that aSHM targets a wide range of genome loci so far only tw ...[more]