Ontology highlight
ABSTRACT:
SUBMITTER: van Golen LW
PROVIDER: S-EPMC3717848 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
van Golen Larissa W LW Huisman Marc C MC Ijzerman Richard G RG Hoetjes Nikie J NJ Schwarte Lothar A LA Lammertsma Adriaan A AA Diamant Michaela M
Diabetes 20130325 8
Subclinical systemic microvascular dysfunction exists in asymptomatic patients with type 1 diabetes. We hypothesized that microangiopathy, resulting from long-standing systemic hyperglycemia and hyperinsulinemia, may be generalized to the brain, resulting in changes in cerebral blood flow (CBF) and metabolism in these patients. We performed dynamic [(15)O]H2O and [(18)F]-fluoro-2-deoxy-d-glucose brain positron emission tomography scans to measure CBF and cerebral glucose metabolism (CMRglu), res ...[more]