Ontology highlight
ABSTRACT:
SUBMITTER: Alam MR
PROVIDER: S-EPMC3718025 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Alam Md Rowshon MR Ming Xin X Fisher Michael M Lackey Jeremy G JG Rajeev Kallanthottathil G KG Manoharan Muthiah M Juliano Rudy L RL
Bioconjugate chemistry 20110720 8
We have designed, synthesized, and tested conjugates of chemically modified luciferase siRNA (Luc-siRNA) with bi-, tri-, and tetravalent cyclic(arginine-glycine-aspartic) (cRGD) peptides that selectively bind to the αvβ3 integrin. The cellular uptake, subcellular distribution, and pharmacological effects of the cRGD-conjugated Luc-siRNAs compared to those of unconjugated controls were examined using a luciferase reporter cassette stably transfected into αvβ3 positive M21(+) human melanoma cells. ...[more]