Ontology highlight
ABSTRACT:
SUBMITTER: Chew TG
PROVIDER: S-EPMC3718791 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130722 7
Mammalian oocytes are arrested at prophase I of meiosis, and resume meiosis prior to ovulation. Coordination of meiotic arrest and resumption is partly dependent on the post-transcriptional regulation of maternal transcripts. Here, we report that, SPINDLIN1 (SPIN1), a maternal protein containing Tudor-like domains, interacts with a known mRNA-binding protein SERBP1, and is involved in regulating maternal transcripts to control meiotic resumption. Mouse oocytes deficient for Spin1 undergo normal ...[more]