Ontology highlight
ABSTRACT:
SUBMITTER: Harvey R
PROVIDER: S-EPMC3718797 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Harvey Robert R Schuster Eugene E Jennings Barbara H BH
PloS one 20130722 7
The early elongation checkpoint regulated by Positive Transcription Elongation Factor b (P-TEFb) is a critical control point for the expression of many genes. Spt5 interacts directly with RNA polymerase II and has an essential role in establishing this checkpoint, and also for further transcript elongation. Here we demonstrate that Drosophila Spt5 interacts both physically and genetically with the Polycomb Group (PcG) protein Pleiohomeotic (Pho), and the majority of Pho binding sites overlap wit ...[more]