A noninvasive tumor oxygenation imaging strategy using magnetic resonance imaging of endogenous blood and tissue water.

ABSTRACT:

Purpose

To present a novel imaging strategy for noninvasive measurement of tumor oxygenation using MR imaging of endogenous blood and tissue water.

Theory and methods

The proposed approach for oxygen partial pressure (pO2) estimation is based on intravoxel incoherent motion diffusion MRI and the dependence of the blood R2 relaxation rate on the inter-echo spacing measured using a multiple spin-echo Carr-Purcell-Meiboom-Gill sequence and weak-field diffusion model. The accuracy of the approach was validated by comparison with (19)F MRI oximetry.

Results

The results in eight rats at 4.7 T showed that tumors have longer T1 (1980 ± 186 ms) and T2 (59 ± 9 ms) relaxation times, heterogeneous blood volume fraction (0.23 ± 0.1), oxygen saturation level (Y) (0.53 ± 0.12), and

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC3718873 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature