Ontology highlight
ABSTRACT:
SUBMITTER: Bruschweiler S
PROVIDER: S-EPMC3719477 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Brüschweiler Sven S Konrat Robert R Tollinger Martin M
ACS chemical biology 20130520 7
The KIX domain of the transcriptional coactivator CREB binding protein (CBP) co-operatively mediates interactions between transcription factors. Binding of the transcription factor mixed-lineage leukemia (MLL) induces the formation of a low-populated conformer of KIX that resembles the conformation of the KIX domain in the presence of a second transcription factor molecule. NMR spin relaxation studies have previously shown that allosteric coupling proceeds through a network of hydrophobic core r ...[more]