Ontology highlight
ABSTRACT:
SUBMITTER: Jordan NV
PROVIDER: S-EPMC3719671 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Jordan Nicole Vincent NV Prat Aleix A Abell Amy N AN Zawistowski Jon S JS Sciaky Noah N Karginova Olga A OA Zhou Bingying B Golitz Brian T BT Perou Charles M CM Johnson Gary L GL
Molecular and cellular biology 20130528 15
We previously identified a gene signature predicted to regulate the epithelial-mesenchymal transition (EMT) in both epithelial tissue stem cells and breast cancer cells. A phenotypic RNA interference (RNAi) screen identified the genes within this 140-gene signature that promoted the conversion of mesenchymal epithelial cell adhesion molecule-negative (EpCAM-) breast cancer cells to an epithelial EpCAM+/high phenotype. The screen identified 10 of the 140 genes whose individual knockdown was suffi ...[more]