Ontology highlight
ABSTRACT:
SUBMITTER: Uruno A
PROVIDER: S-EPMC3719683 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Uruno Akira A Furusawa Yuki Y Yagishita Yoko Y Fukutomi Toshiaki T Muramatsu Hiroyuki H Negishi Takaaki T Sugawara Akira A Kensler Thomas W TW Yamamoto Masayuki M
Molecular and cellular biology 20130528 15
Transcription factor Nrf2 (NF-E2-related factor 2) regulates a broad cytoprotective response to environmental stresses. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor protein for cullin3-based ubiquitin E3 ligase and negatively regulates Nrf2. Whereas the Keap1-Nrf2 system plays important roles in oxidative stress response and metabolism, the roles Nrf2 plays in the prevention of diabetes mellitus remain elusive. Here we show that genetic activation of Nrf2 signaling by Keap1 gene hyp ...[more]