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First report of the multiresistance gene cfr in Streptococcus suis.

ABSTRACT: The multiresistance gene cfr was identified for the first time in streptococci, namely, in porcine Streptococcus suis isolate S10. The cfr gene was detected on the ~100-kb plasmid pStrcfr, where it was bracketed by two copies of the novel insertion sequence ISEnfa5, located in the same orientation. The detection of a cfr- and ISEnfa5-containing amplicon by inverse PCR suggests that ISEnfa5 may play a role in the dissemination of cfr.

SUBMITTER: Wang Y

PROVIDER: S-EPMC3719703 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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First report of the multiresistance gene cfr in Streptococcus suis.

Wang Yang Y Li Dexi D Song Li L Liu Yang Y He Tao T Liu Hebing H Wu Congming C Schwarz Stefan S Shen Jianzhong J

Antimicrobial agents and chemotherapy 20130603 8

The multiresistance gene cfr was identified for the first time in streptococci, namely, in porcine Streptococcus suis isolate S10. The cfr gene was detected on the ~100-kb plasmid pStrcfr, where it was bracketed by two copies of the novel insertion sequence ISEnfa5, located in the same orientation. The detection of a cfr- and ISEnfa5-containing amplicon by inverse PCR suggests that ISEnfa5 may play a role in the dissemination of cfr. ...[more]

PMID: 23733472

Similar Datasets

Clostridium difficile isolates with high linezolid MICs harbor the multiresistance gene cfr.

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IS21-558 insertion sequences are involved in the mobility of the multiresistance gene cfr.

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First report of the multidrug resistance gene cfr in Enterococcus faecalis of animal origin.

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First human case report of sepsis due to infection with Streptococcus suis serotype 31 in Thailand.

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Transferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment.

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| S-EPMC3535926 | biostudies-literature

Characterization of the IncA/C plasmid pSCEC2 from Escherichia coli of swine origin that harbours the multiresistance gene cfr.

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| S-EPMC3937595 | biostudies-literature

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| S-EPMC2935014 | biostudies-literature

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| S-EPMC5700312 | biostudies-literature

Carbohydrate availability regulates virulence gene expression in Streptococcus suis.

Project description:Streptococcus suis is a major bacterial pathogen of young pigs causing worldwide economic problems for the pig industry. S. suis is also an emerging pathogen of humans. Colonization of porcine oropharynx by S. suis is considered to be a high risk factor for invasive disease. In the oropharyngeal cavity, where glucose is rapidly absorbed but dietary α-glucans persist, there is a profound effect of carbohydrate availability on the expression of virulence genes. Nineteen predicted or confirmed S. suis virulence genes that promote adhesion to and invasion of epithelial cells were expressed at higher levels when S. suis was supplied with the α-glucan starch/pullulan compared to glucose as the single carbon source. Additionally the production of suilysin, a toxin that damages epithelial cells, was increased more than ten-fold when glucose levels were low and S. suis was growing on pullulan. Based on biochemical, bioinformatics and in vitro and in vivo gene expression studies, we developed a biological model that postulates the effect of carbon catabolite repression on expression of virulence genes in the mucosa, organs and blood. This research increases our understanding of S. suis virulence mechanisms and has important implications for the design of future control strategies including the development of anti-infective strategies by modulating animal feed composition.

| S-EPMC3958366 | biostudies-literature

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