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CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group ?-lactamases recovered from Escherichia coli isolates in China.

ABSTRACT: The chimeric bla(CTX-M-123) gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla(CTX-M-123) is carried on related, but not identical, ~90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 blaCTX-M-55 gene on an additional IncI2 plasmid.

SUBMITTER: He D

PROVIDER: S-EPMC3719705 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group β-lactamases recovered from Escherichia coli isolates in China.

He Dandan D Partridge Sally R SR Shen Jianzhong J Zeng Zhenling Z Liu Lanping L Rao Lili L Lv Luchao L Liu Jian-Hua JH

Antimicrobial agents and chemotherapy 20130610 8

The chimeric bla(CTX-M-123) gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla(CTX-M-123) is carried on related, but not identical, ~90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 blaCTX-M-55 ...[more]

PMID: 23752509

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