Ontology highlight
ABSTRACT:
SUBMITTER: Khoury K
PROVIDER: S-EPMC3719986 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
The protein-protein interaction (PPI) between p53 and its negative regulator MDM2 comprises one of the most important and intensely studied PPI's involved in preventing the initiation of cancer. The interaction between p53 and MDM2 is conformation-based and is tightly regulated on multiple levels. Due to the Angstrom level structural insight there is a reasonable understanding of the structural requirements needed for a molecule to bind to MDM2 and successfully inhibit the p53/MDM2 interaction. ...[more]