Downregulation of Col1a1 induces differentiation in mouse spermatogonia.
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ABSTRACT:
SUBMITTER: Chen SH
PROVIDER: S-EPMC3720107 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Downregulation of Col1a1 induces differentiation in mouse spermatogonia.
Chen Sun-Hong SH Li Ding D Xu Chen C
Asian journal of andrology 20121015 6
Col1a1 (one of the subunit of collagen type I) is a collagen, which belongs to a family of extracellular matrix (ECM) proteins that play an important role in cellular proliferation and differentiation. However, the role of Col1a1 in spermatogenesis, especially in the control of proliferation and differentiation of spermatogonial stem cells (SSCs), remains unknown. In this study, we explored effects of downregulation of Col1a1 on differentiation and proliferation of mouse spermatogonia. Loss-of-f ...[more]
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