Genetic variants in hormone-related genes and risk of breast cancer.
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ABSTRACT:
SUBMITTER: Clendenen T
PROVIDER: S-EPMC3720532 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Genetic variants in hormone-related genes and risk of breast cancer.
Clendenen Tess T Zeleniuch-Jacquotte Anne A Wirgin Isaac I Koenig Karen L KL Afanasyeva Yelena Y Lundin Eva E Arslan Alan A AA Axelsson Tomas T Försti Asta A Hallmans Göran G Hemminki Kari K Lenner Per P Roy Nirmal N Shore Roy E RE Chen Yu Y
PloS one 20130723 7
Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 ...[more]
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