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Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer.

ABSTRACT: Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was negatively correlated with c-Myb expression. NLK suppressed proliferation, induced apoptosis and mediated c-Myb degradation in MCF-7 cells via a mechanism that seems to involve c-myc and Bcl2. These findings might provide a novel target for therapeutic intervention in patients with breast cancer.

SUBMITTER: Huang Y

PROVIDER: S-EPMC3720543 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer.

Huang Yeqing Y Jiang Ying Y Lu Weiqi W Zhang Yong Y

PloS one 20130723 7

Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was negatively correlated with c-Myb expression. NLK suppressed proliferation, induced apoptosis and mediated c-Myb degradation in MCF-7 cells via a mechanism that seems to involve c-myc and Bcl2. These ...[more]

PMID: 23935942

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Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.

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2021-01-11 | GSE141696 | GEO

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Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.

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