Ontology highlight
ABSTRACT:
SUBMITTER: Ashoor A
PROVIDER: S-EPMC3720735 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ashoor Abrar A Nordman Jacob C JC Veltri Daniel D Yang Keun-Hang Susan KH Al Kury Lina L Shuba Yaroslav Y Mahgoub Mohamed M Howarth Frank C FC Sadek Bassem B Shehu Amarda A Kabbani Nadine N Oz Murat M
PloS one 20130723 7
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined. In this study we show an effect of menthol on the α7 subunit of the nicotinic acetylcholine (nACh) receptor function. Using a two-electrode voltage-clamp technique, menthol was found to reversibly inhibit α7-nACh receptors heterologously expressed in Xenopus oocytes. Inhibition by menthol was not dependent on the membrane potential a ...[more]