Ontology highlight
ABSTRACT:
SUBMITTER: Song SH
PROVIDER: S-EPMC3720789 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Song Sang-Hyun SH Kim Aeri A Dale Ryan R Dean Ann A
Biochimica et biophysica acta 20120518 8
Carbonic anhydrase 1 (Car1), an early specific marker of the erythroid differentiation, has been used to distinguish fetal and adult erythroid cells since its production closely follows the γ- to β-globin transition, but the molecular mechanism underlying transcriptional regulation of Car1 is unclear. Here, we show that Car1 mRNA decreases significantly when erythroid differentiation is induced in MEL cells. The Ldb1 protein complex including GATA1/SCL/LMO2 binds to the Car1 promoter in uninduce ...[more]