A patterned recombinant human IgM guides neurite outgrowth of CNS neurons.
Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC3721078 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
A patterned recombinant human IgM guides neurite outgrowth of CNS neurons.
Xu Xiaohua X Wittenberg Nathan J NJ Jordan Luke R LR Kumar Shailabh S Watzlawik Jens O JO Warrington Arthur E AE Oh Sang-Hyun SH Rodriguez Moses M
Scientific reports 20130101
Matrix molecules convey biochemical and physical guiding signals to neurons in the central nervous system (CNS) and shape the trajectory of neuronal fibers that constitute neural networks. We have developed recombinant human IgMs that bind to epitopes on neural cells, with the aim of treating neurological diseases. Here we test the hypothesis that recombinant human IgMs (rHIgM) can guide neurite outgrowth of CNS neurons. Microcontact printing was employed to pattern rHIgM12 and rHIgM22, antibodi ...[more]
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