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Secondary metabolites from Penicillium pinophilum SD-272, a marine sediment-derived fungus.

ABSTRACT: Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD?? 11.2 ?M.

SUBMITTER: Wang MH

PROVIDER: S-EPMC3721231 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Secondary metabolites from Penicillium pinophilum SD-272, a marine sediment-derived fungus.

Wang Ming-Hui MH Li Xiao-Ming XM Li Chun-Shun CS Ji Nai-Yun NY Wang Bin-Gui BG

Marine drugs 20130621 6

Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of ...[more]

PMID: 23792827

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