Caspase substrates and inhibitors.
Ontology highlight
ABSTRACT:
SUBMITTER: Poreba M
PROVIDER: S-EPMC3721276 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Caspase substrates and inhibitors.
Poreba Marcin M Strózyk Aleksandra A Salvesen Guy S GS Drag Marcin M
Cold Spring Harbor perspectives in biology 20130801 8
Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through the development of synthetic substrates and inhibitors. Such agents are used to define the role of caspases in transmitting life and death signals, in imaging caspases in situ and in vivo, and in deconvoluting the networks that govern cell behavior. Additionally, focused proteomics methods have begu ...[more]
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