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Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer.

ABSTRACT:

Background

Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.

Methods

We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.

Results

PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.

Conclusion

PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.

SUBMITTER: Takahashi Y

PROVIDER: S-EPMC3721401 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer.

Takahashi Y Y Sawada G G Kurashige J J Uchi R R Matsumura T T Ueo H H Takano Y Y Akiyoshi S S Eguchi H H Sudo T T Sugimachi K K Doki Y Y Mori M M Mimori K K

British journal of cancer 20130627 2

<h4>Background</h4>Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.<h4>Methods</h4>We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.<h4>Results</h4>PRRX1 induced EMT and the stem-like phenotype in CRC cells. ...[more]

PMID: 23807160

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