Ontology highlight
ABSTRACT:
SUBMITTER: Cassat JE
PROVIDER: S-EPMC3721972 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cassat James E JE Hammer Neal D ND Campbell J Preston JP Benson Meredith A MA Perrien Daniel S DS Mrak Lara N LN Smeltzer Mark S MS Torres Victor J VJ Skaar Eric P EP
Cell host & microbe 20130601 6
Osteomyelitis is a common manifestation of invasive Staphylococcus aureus infection. Pathogen-induced bone destruction limits antimicrobial penetration to the infectious focus and compromises treatment of osteomyelitis. To investigate mechanisms of S. aureus-induced bone destruction, we developed a murine model of osteomyelitis. Microcomputed tomography of infected femurs revealed that S. aureus triggers profound alterations in bone turnover. The bacterial regulatory locus sae was found to be cr ...[more]