Ontology highlight
ABSTRACT:
SUBMITTER: Csordas G
PROVIDER: S-EPMC3722067 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Csordás György G Golenár Tünde T Seifert Erin L EL Kamer Kimberli J KJ Sancak Yasemin Y Perocchi Fabiana F Moffat Cynthia C Weaver David D Perez Sergio de la Fuente SF Bogorad Roman R Koteliansky Victor V Adijanto Jeffrey J Mootha Vamsi K VK Hajnóczky György G
Cell metabolism 20130601 6
Mitochondrial Ca(2+) uptake via the uniporter is central to cell metabolism, signaling, and survival. Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF-hand protein, as its critical regulator. How this complex decodes dynamic cytoplasmic [Ca(2+)] ([Ca(2+)]c) signals, to tune out small [Ca(2+)]c increases yet permit pulse transmission, remains unknown. We report that loss of MICU1 in mouse liver and cultured cells causes mitochondrial Ca(2+) accumulation during small [ ...[more]