Development of prophylactic vaccines against HIV-1.
Ontology highlight
ABSTRACT:
SUBMITTER: Schiffner T
PROVIDER: S-EPMC3722125 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Development of prophylactic vaccines against HIV-1.
Schiffner Torben T Sattentau Quentin J QJ Dorrell Lucy L
Retrovirology 20130717
The focus of most current HIV-1 vaccine development is on antibody-based approaches. This is because certain antibody responses correlated with protection from HIV-1 acquisition in the RV144 phase III trial, and because a series of potent and broad spectrum neutralizing antibodies have been isolated from infected individuals. Taken together, these two findings suggest ways forward to develop a neutralizing antibody-based vaccine. However, understanding of the correlates of protection from diseas ...[more]
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