Dataset Information

Novel pneumoviruses (PnVs): Evolution and inflammatory pathology.

ABSTRACT: A previous report of a novel pneumovirus (PnV) isolated from the respiratory tract of a dog described its significant homology to the rodent pathogen, pneumonia virus of mice (PVM). The original PnV-Ane4 pathogen replicated in and could be re-isolated in infectious state from mouse lung but elicited minimal mortality compared to PVM strain J3666. Here we assess phylogeny and physiologic responses to 10 new PnV isolates. The G/glycoprotein sequences of all PnVs include elongated amino-termini when compared to the characterized PVMs, and suggest division into groups A and B. While we observed significant differences in cytokine production and neutrophil recruitment to the lungs of BALB/c mice in response to survival doses (50 TCID50 units) of representative group A (114378-10-29-KY-F) and group B (7968-11-OK) PnVs, we observed no evidence for positive selection (dN > dS) among the PnV/PnV, PVM/PnV or PVM/PVM G/glycoprotein or F/fusion protein sequence pairs.

SUBMITTER: Glineur SF

PROVIDER: S-EPMC3722285 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Novel pneumoviruses (PnVs): Evolution and inflammatory pathology.

Glineur Stephanie F SF Renshaw Randall W RW Percopo Caroline M CM Dyer Kimberly D KD Dubovi Edward J EJ Domachowske Joseph B JB Rosenberg Helene F HF

Virology 20130610 2

A previous report of a novel pneumovirus (PnV) isolated from the respiratory tract of a dog described its significant homology to the rodent pathogen, pneumonia virus of mice (PVM). The original PnV-Ane4 pathogen replicated in and could be re-isolated in infectious state from mouse lung but elicited minimal mortality compared to PVM strain J3666. Here we assess phylogeny and physiologic responses to 10 new PnV isolates. The G/glycoprotein sequences of all PnVs include elongated amino-termini whe ...[more]

PMID: 23763766

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Dataset Information

Novel pneumoviruses (PnVs): Evolution and inflammatory pathology.

Publications

Novel pneumoviruses (PnVs): Evolution and inflammatory pathology.

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