Dataset Information

Drug-target interaction prediction through domain-tuned network-based inference.

ABSTRACT:

Motivation

The identification of drug-target interaction (DTI) represents a costly and time-consuming step in drug discovery and design. Computational methods capable of predicting reliable DTI play an important role in the field. Recently, recommendation methods relying on network-based inference (NBI) have been proposed. However, such approaches implement naive topology-based inference and do not take into account important features within the drug-target domain.

Results

In this article, we present a new NBI method, called domain tuned-hybrid (DT-Hybrid), which extends a well-established recommendation technique by domain-based knowledge including drug and target similarity. DT-Hybrid has been extensively tested using the last version of an experimentally validated DTI database obtained from DrugBank. Comparison with other recently proposed NBI methods clearly shows that DT-Hybrid is capable of predicting more reliable DTIs.

Availability

DT-Hybrid has been developed in R and it is available, along with all the results on the predictions, through an R package at the following URL: http://sites.google.com/site/ehybridalgo/.

SUBMITTER: Alaimo S

PROVIDER: S-EPMC3722516 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Publications

Drug-target interaction prediction through domain-tuned network-based inference.

Alaimo Salvatore S Pulvirenti Alfredo A Giugno Rosalba R Ferro Alfredo A

Bioinformatics (Oxford, England) 20130529 16

<h4>Motivation</h4>The identification of drug-target interaction (DTI) represents a costly and time-consuming step in drug discovery and design. Computational methods capable of predicting reliable DTI play an important role in the field. Recently, recommendation methods relying on network-based inference (NBI) have been proposed. However, such approaches implement naive topology-based inference and do not take into account important features within the drug-target domain.<h4>Results</h4>In this ...[more]

PMID: 23720490

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Dataset Information

Drug-target interaction prediction through domain-tuned network-based inference.

Motivation

Results

Availability

Publications

Drug-target interaction prediction through domain-tuned network-based inference.

Similar Datasets

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