Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
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ABSTRACT:
SUBMITTER: Orr N
PROVIDER: S-EPMC3722904 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
Orr Nick N Lemnrau Alina A Cooke Rosie R Fletcher Olivia O Tomczyk Katarzyna K Jones Michael M Johnson Nichola N Lord Christopher J CJ Mitsopoulos Costas C Zvelebil Marketa M McDade Simon S SS Buck Gemma G Blancher Christine C Trainer Alison H AH James Paul A PA Bojesen Stig E SE Bokmand Susanne S Nevanlinna Heli H Mattson Johanna J Friedman Eitan E Laitman Yael Y Palli Domenico D Masala Giovanna G Zanna Ines I Ottini Laura L Giannini Giuseppe G Hollestelle Antoinette A Ouweland Ans M W van den AM Novaković Srdjan S Krajc Mateja M Gago-Dominguez Manuela M Castelao Jose Esteban JE Olsson Håkan H Hedenfalk Ingrid I Easton Douglas F DF Pharoah Paul D P PD Dunning Alison M AM Bishop D Timothy DT Neuhausen Susan L SL Steele Linda L Houlston Richard S RS Garcia-Closas Montserrat M Ashworth Alan A Swerdlow Anthony J AJ
Nature genetics 20120923 11
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50). ...[more]
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