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Changing profile of rotavirus genotypes in Bangladesh, 2006-2012.


ABSTRACT: BACKGROUND: Rotavirus is the leading cause of severe diarrhea in infants and young children worldwide including Bangladesh. Unlike what was seen in high-income countries, the licensed rotavirus vaccines did not show high efficacy in Bangladeshi trials. We assessed rotavirus prevalence and genotypes in Bangladesh over six-year period to provide baseline information on the rotavirus burden and changing profile in the country. METHODS: This study was conducted from June 2006 to May 2012 in Matlab, Bangladesh. Group A rotaviruses were detected in stools collected from diarrhea patients by ELISA and genotyped using multiplex reverse transcription PCR followed by nucleotide sequencing. RESULTS: Of the 9678 stool samples, 20.3% were positive for rotavirus. The most predominant genotype was G1P[8] (22.4%), followed by G9P[8] (20.8%), G2P[4] (16.9%) and G12P[8] (10.4%). Mixed infections were detected in 14.2% of the samples. Emergence of an unusual strain, G9P[4] was documented during 2011-12. Several amino acid mismatches in the antigenic epitopes of VP7 and VP4 between Bangladeshi and the vaccine strains were identified. CONCLUSIONS: Our study provides important information on rotavirus genotypes that should be considered for the selection and introduction of rotavirus vaccines in Bangladesh.

SUBMITTER: Afrad MH 

PROVIDER: S-EPMC3723515 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Changing profile of rotavirus genotypes in Bangladesh, 2006-2012.

Afrad Mokibul Hassan MH   Hassan Zahid Z   Farjana Saiada S   Moni Sayra S   Barua Subarna S   Das Sumon Kumar SK   Faruque Abu Syed Golam AS   Azim Tasnim T   Rahman Mustafizur M  

BMC infectious diseases 20130715


<h4>Background</h4>Rotavirus is the leading cause of severe diarrhea in infants and young children worldwide including Bangladesh. Unlike what was seen in high-income countries, the licensed rotavirus vaccines did not show high efficacy in Bangladeshi trials. We assessed rotavirus prevalence and genotypes in Bangladesh over six-year period to provide baseline information on the rotavirus burden and changing profile in the country.<h4>Methods</h4>This study was conducted from June 2006 to May 201  ...[more]

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