Dataset Information

CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users.

ABSTRACT:

Background

Up to 90% HIV-1 positive intravenous drug users (IDUs) are co-infected with HCV. Although best recognized for its function as a major co-receptor for cell entry of HIV, CC chemokine receptor 5 (CCR5) has also been implicated in the pathogenesis of HCV infection. Here, we investigated whether CCR5 haplotypes influence HIV-1 and HCV seropositivity among 373 Caucasian IDUs from Estonia.

Methods

Of these IDUs, 56% and 44% were HIV and HCV seropositive, respectively, and 47% were coinfected. 500 blood donors seronegative for HIV and HCV were also evaluated. CCR5 haplotypes (HHA to HHG*2) were derived after genotyping nine CCR2-CCR5 polymorphisms. The association between CCR5 haplotypes with HIV and/or HCV seropositivity was determined using logistic regression analysis. Co-variates included in the models were length of intravenous drug use, HBV serostatus and copy number of CCL3L1, the gene encoding the most potent HIV-suppressive chemokine and ligand for CCR5.

Results

Compared to IDUs seronegative for both HCV and HIV (HCV-/HIV-), IDUs who were HCV+/HIV- and HCV+/HIV+were 92% and 82%, respectively, less likely to possess the CCR5-HHG*1 haplotype, after controlling for co-variates (P(adjusted) = 1.89 × 10(-4) and 0.003, respectively). This association was mostly due to subjects bearing the CCR5 HHE and HHG*1 haplotype pairs. Approximately 25% and<10% of HCV-/HIV- IDUs and HCV-/HIV- blood donors, respectively, possessed the HHE/HHG*1 genotype.

Conclusions

Our findings suggest that HHG*1-bearing CCR5 genotypes influence HCV seropositivity in a group of Caucasian IDUs.

SUBMITTER: Huik K

PROVIDER: S-EPMC3723663 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users.

Huik Kristi K Avi Radko R Carrillo Andrew A Harper Nathan N Pauskar Merit M Sadam Maarja M Karki Tõnis T Krispin Tõnu T Kongo Ulvi-Kaire UK Jermilova Tatiana T Rüütel Kristi K Talu Ave A Abel-Ollo Katri K Uusküla Anneli A Ahuja Sunil K SK He Weijing W Lutsar Irja I

PloS one 20130725 7

<h4>Background</h4>Up to 90% HIV-1 positive intravenous drug users (IDUs) are co-infected with HCV. Although best recognized for its function as a major co-receptor for cell entry of HIV, CC chemokine receptor 5 (CCR5) has also been implicated in the pathogenesis of HCV infection. Here, we investigated whether CCR5 haplotypes influence HIV-1 and HCV seropositivity among 373 Caucasian IDUs from Estonia.<h4>Methods</h4>Of these IDUs, 56% and 44% were HIV and HCV seropositive, respectively, and 47% ...[more]

PMID: 23936229

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Dataset Information

CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users.

Background

Methods

Results

Conclusions

Publications

CCR5 haplotypes influence HCV serostatus in Caucasian intravenous drug users.

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