Ontology highlight
ABSTRACT:
SUBMITTER: Mostowska A
PROVIDER: S-EPMC3723978 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Mostowska Adrianna A Sajdak Stefan S Pawlik Piotr P Lianeri Margarita M Jagodzinski Paweł P PP
Molecular biology reports 20130512 8
Studies have demonstrated that changes in DNA methylation of cancer related genes can be an elementary process accounting for ovarian tumorigenesis. Therefore, we evaluated the possible association of single nucleotide polymorphisms (SNPs) of DNA methyltransferases (DNMTs) genes, including DNMT1, DNMT3B, and DNMT3A, with ovarian cancer development in the Polish population. Using PCR-RFLP and HRM analyses, we studied the prevalence of the DNMT1 rs8101626, rs2228611 and rs759920, DNMT3A rs2289195, ...[more]