Ontology highlight
ABSTRACT:
SUBMITTER: Pantazaka E
PROVIDER: S-EPMC3724117 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
British journal of pharmacology 20130801 7
<h4>Background and purpose</h4>Histamine and prostaglandin E2 (PGE2 ), directly and via their effects on other cells, regulate the behaviour of vascular smooth muscle (VSM), but their effects on human VSM are incompletely resolved.<h4>Experimental approach</h4>The effects of PGE2 on histamine-evoked changes in intracellular free Ca(2+) concentration ([Ca(2+) ]i ) and adenylyl cyclase activity were measured in populations of cultured human aortic smooth muscle cells (ASMCs). Selective ligands of ...[more]