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Mass fabrication and delivery of 3D multilayer ?Tags into living cells.

ABSTRACT: Continuous monitoring of in vivo biological processes and their evolution at the cellular level would enable major advances in our understanding of biology and disease. As a stepping stone towards chronic cellular monitoring, we demonstrate massively parallel fabrication and delivery of 3D multilayer micro-Tags (?Tags) into living cells. Both 10 ?m × 10 ?m × 1.5 ?m and 18 ?m × 7 ?m × 1.5 ?m devices containing inductive and capacitive structures were designed and fabricated as potential passive radio-frequency identification tags. We show cellular internalization and persistence of ?Tags over a 5-day period. Our results represent a promising advance in technologies for studying biology and disease at the cellular level.

SUBMITTER: Chen LY

PROVIDER: S-EPMC3724179 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Mass fabrication and delivery of 3D multilayer μTags into living cells.

Chen Lisa Y LY Parizi Kokab B KB Kosuge Hisanori H Milaninia Kaveh M KM McConnell Michael V MV Wong H-S Philip HS Poon Ada S Y AS

Scientific reports 20130101

Continuous monitoring of in vivo biological processes and their evolution at the cellular level would enable major advances in our understanding of biology and disease. As a stepping stone towards chronic cellular monitoring, we demonstrate massively parallel fabrication and delivery of 3D multilayer micro-Tags (μTags) into living cells. Both 10 μm × 10 μm × 1.5 μm and 18 μm × 7 μm × 1.5 μm devices containing inductive and capacitive structures were designed and fabricated as potential passive r ...[more]

PMID: 23887586

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